Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic products.

Background: Ensuring the toxicological safety of fragrance ingredients used in personal care and cosmetic products is essential in product development and design, as well as in the regulatory compliance of the products. This requires an accurate estimation of consumer exposure which, in turn, requires an understanding of consumer habits…

Authors: Safford B., A.M.Api, C.Barratt, D.Comiskey, G.Ellis, E.J. Daly, C.McNamara, C.O’Mahony, S.Robison, B.Smith, S.Tozeri

Publication date: 01/08/2015

All Publications, Chemicals, Fragrances, Personal Care, Technology

European consumer exposure to cosmetic products, a framework for conducting population exposure assessments Part 2.

Access to reliable exposure data is essential for the evaluation of the toxicological safety of ingredients in cosmetic products. This study complements the data set obtained previously (Part 1) and published in 2007 by the European cosmetic industry acting within COLIPA. It provides, in distribution form, exposure data on…

Authors: Hall B, Steiling W, Safford B, Coroama M, Tozer S, Firmani C, McNamara C, Gibney M.

Publication date: 18/11/2010

All Publications, Chemicals, Exposure, Personal Care, Technology

Probabilistic modelling of European consumer exposure to cosmetic products.

In this study, we describe the statistical analysis of the usage profile of the European population to seven cosmetic products. The aim of the study was to construct a reliable model of exposure of the European population from use of the selected products: body lotion, shampoo, deodorant spray, deodorant…

Authors: McNamara C, Rohan D, Golden D, Gibney M, Hall B, Tozer S, Safford B, Coroama M, Leneveu-Duchemin MC, Steiling W.

Publication date: 07/07/2007

All Publications, Chemicals, Exposure, Personal Care, Technology

European consumer exposure to cosmetic products, a framework for conducting population exposure assessments.

Access to reliable exposure data is essential to evaluate the toxicological safety of ingredients in cosmetic products. This study was carried out by European cosmetic manufacturers acting within the trade association Colipa, with the aim to construct a probabilistic European population model of exposure. The study updates, in distribution…

Authors: Hall B, Tozer S, Safford B, Coroama M, Steiling W, Leneveu-Duchemin MC, McNamara C, Gibney M.

Publication date: 16/06/2007

All Publications, Chemicals, Exposure, Personal Care, Technology

Aggregate exposure modelling of zinc pyrithione in rinse-off personal cleansing products using a person-orientated approach with market share refinement.

Realistic estimates of chemical aggregate exposure are needed to ensure consumer safety. As exposure estimates are a critical part of the equation used to calculate acceptable “safe levels” and conduct quantitative risk assessments, methods are needed to produce realistic exposure estimations. To this end, a probabilistic aggregate exposure model…

Authors: Tozer S, Kelly S, O’Mahony C, Daly EJ, Nash JF.

Publication date: 16/06/2015

All Publications, Chemicals, Exposure, Personal Care

Models for estimating human exposure to pesticides, Outlooks on Pest Management

Any quantitative understanding of human risk from exposure to pesticides requires knowledge of both hazard (the intrinsic ability of a pesticide to cause harm) and exposure (absorbed dose), i.e., risk is directly proportional to the product of hazard and exposure. Thus, regardless of potential high hazard, risk may be…

Authors: Ross John; Driver, Jeffrey; Lunchick, Curt; O’Mahony, Cian

Publication date: 01/02/2015

All Publications, Chemicals, Exposure, Food Safety, Technology

Longitudinal modelling of the exposure of young UK patients with PKU to acesulfame K and sucralose

Artificial sweeteners are used in protein substitutes intended for the dietary management of inborn errors of metabolism (phenylketonuria, PKU) to improve the variety of medical foods available to patients and ensure dietary adherence to the prescribed course of dietary management. These patients can be exposed to artificial sweeteners from…

Authors: O’Sullivan AJ, S Pigat, C O’Mahony, MJ Gibney, AI McKevitt

Publication date: 23/08/2017

All Publications, Chemicals, Exposure, Food Safety

Probabilistic Bioactive Food Compound Intakes in the European BACCHUS Project

The EU funded BACCHUS project aims to develop tools and resources to study relationships between bioactive food compound intakes and cardiovascular health in humans. To handle variation and uncertainty of bioactive levels in foods a probabilistic model of bioactive intakes was used to estimate distributions of population intakes….

Authors: Pigat Sandrine, Rosalyn O’Connor

Publication date: 01/04/2015

All Publications, Chemicals, Exposure, Food Safety, Nutrition

ECETOC Technical Report no.126: Guidance for effective use of human exposure data in risk assessment of chemicals

This report details much of the current state-of-the-art of consumer exposure assessment data and models that can be used in chemical risk assessment, with a particular focus upon aggregate exposure assessment. Aggregate exposure considers all sources of exposure to a single chemical (e.g. hair care products, cosmetics, detergents, foods,…

Authors: O’Mahony C. et al on behalf of the ECETOC Task Force on guidance for effective use of human exposure data in risk assessment of chemicals

Publication date: 01/11/2016

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