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From worst-case to reality – Case studies illustrating tiered refinement of consumer exposure to cosmetic ingredients

Consumer exposure to cosmetic ingredients is estimated in a tiered manner. Simple Tier1 deterministic aggregate exposure modelling generates a worst case estimate of exposure. Tier1 assumes that a consumer uses all cosmetic products concomitantly daily, at maximum frequency, and products always contain the ingredient at the maximum allowed %…
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Authors: Sarah Tozer, Camilla Alexander-White, Ripal Amin, Françoise Audebert, Catherine Barratt, John O’Brien, Tim Burke, Dagmar Bury, Hermine Dika Nguea, Myrto Dimopoulou, Sarah Farahmand, Sabrina Fritz, Elisabeth Gerber, Arianna Giusti, William Goodwin, Taryn Kirsch, Victor Oreffo, Cronan McNamara
Publication date: 01/09/2023

Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment – A case study with parabens

Parabens are esters of para-hydroxybenzoic acid that have been used as preservatives in many types of products for decades including agrochemicals, pharmaceuticals, food and cosmetics. This illustrative case study with propylparaben (PP) demonstrates a 10-step read-across (RAX) framework in practice. It aims at establishing a proof-of-concept for the value…
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Authors: Gladys Ouedraogo a, Camilla Alexander-White b, Dagmar Bury c, Harvey J. Clewell III d, Mark Cronin e, Tom Cull f, Matthew Dent f, Bertrand Desprez g, Ann Detroyer a, Corie Ellison h, Stefania Giammanco i, Eric Hack j, Nicola J. Hewitt k, Gerry Kenna l, Martina Klaric g, Reinhard Kreiling m, Cathy Lester n, Catherine Mahony n, Enrico Mombelli o, Jorge Naciff h, John O’Brien i, Andreas Schepky p, Sarah Tozer n, Bart van der Burg q, Barbara van Vugt-Lussenburg q, Sharon Stuard h, Cosmetics Europe
Publication date: 01/05/2022

Analysis of usage patterns and probabilistic risk assessment of personal care products in Korea

In daily life, many people use large amounts of personal care products (PCPs) on a regular basis. For determining the risk to consumers, product usage amount, frequency of use, and co-use patterns are essential information. In this study, the PCP usage patterns of Korean consumers were analyzed, and the…
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Authors: KeunOh Choi,Namkyu Lee, Yoonhee Uhm, Joo Won Kim, Eunkyung Lim, YoungJoo Lee
Publication date: 04/10/2022
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